Another thing "..vs Aliens" that cinema introduced us to a long while ago was the (british?) movie "Attack the Block".
The plot of the movie could as well be summed up as "hoodlums vs aliens". The conflict is not the large scale invasion here, and the aliens aren´t using any advanced technology. It is more like a large pack of invisible-in-the-dark, predatory apelike creatures attacking a highrise building in the bad parts of a city at night.
This -could- be turned into a one-shot adventure, so. The GM would need to define clique inside the highrise (the player characters), the people living in the different levels of the high rise and the attackers. The game would see the attacker coming in at the lowest point, while the PC try to fend them off while fleeing upwards, trying to rally enough of the other behind them. Despite the fact that nobody will believe them at start, some are on bad terms with them for some reason or the other, and don´t make me start about the thugs running a hidden meth lab in the 7th floor. You know, those guys who used to knock the sh*t out of you if you come to "their" storie of the building while not being one of their courier runners. Hey, Sammy is one of their couriers, right? Let´s get up to the 8th floor and see if the 14 year old is home.
"Pacing" would be the name of the game here for the GM, as the characters need to be kept under pressure, with groups and waves of new attackers and problems coming in. Can they fend off the aliens long enough for some help actually showing up?