The not-quite-elephant in the room for Cryptworld, I think, is that the official Chill background was split off (and not part of Goblinoid Games' acquisition of Pacesetter properties) ... and this mainly means the S.A.V.E. organization.
Of course, CMs are free to include it (the first or second edition incarnations) regardless. CW instead comes with more advice on creating organizations, and offers some new samples (ISCX, DAPA, Smithsonian Institute's Special Collections Division, the Societas Malleus et Sudis, and the Weekly Inquisitor). All nifty(and SMeS is likely closest in spirit - heh - to S.A.V.E.
One thought I've had is to pull a reboot and capitalize on the history - and death - of the old S.A.V.E. My recollection - I don't have my 2nd ed book on hand atm- is that S.A.V.E. was under strong (counter)attack by the Unknown, loosing chapter houses and effectively gone underground and scattered if not dead. This was at the timeline of the last published edition of Chill, of course, and about 20-ish years ago if CMs are picking up with a contemporary release of CW.
So, my idea is to have PCs be legacies of S.A.V.E. Envoys - children, relatives, children of associates ... whatever. 20 - 30 years ago, they disappeared, died. The first adventure could bring the PCs together, and either set up a commonality or have the 2nd adventure hook relate to it. The PCs begin to learn about the role the Unknown has had in their past, the destruction of this unnamed group, and a strong reminder to be highly cautious in the future. The Unknown perhaps has even lost track of the descendants, assuming their destruction so complete.
Thoughts? What are folks using for their PC organizations, if any?