My players have been working out of the city of Pentastadion for some time now, and love the flavor. The city was originally written up for the world of Fomalhaut by Gabor Lux and appeared in Fight On! magazine #5. It was simple with some great ideas and we've taken it and made it our own--kind of a Moroccan/Turkish-type seacoast city ruled by wealthy merchants and full of odd characters. The party has explored the countryside some and had a few city adventures, but most recently started to explore the undercity and the labyrinths below. I drew up a side-view of the main levels and let the "map" get into the hands of the PCs. They're excited about it, so I'm starting to make a legit megadungeon out of it. Never actually executed this kind of creation, though I've started a couple and read a lot online about it.
I'll be posting some ideas and questions here as I work, and I'd be really happy to hear any advice from you guys.
Oh, and John, Brian, and Bob, if you are reading this---stop! Don't ruin your fun by reading on.